# SPYRE THERAPEUTICS INC COM NEW

SPYRE THERAPEUTICS INC COM NEW is a security (CUSIP 00773J202) tracked across SEC portfolio filings. 209 institutional managers reported $4.2B on Form 13F as of 2026-06-30; 27 registered fund positions totaling $493.4M via N-PORT as of 2026-05-31.

## Summary

- Issuer: SPYRE THERAPEUTICS INC
- Class: COM NEW
- CUSIP: 00773J202
- Asset category: EC
- 13F holders: 209
- 13F value: $4.2B
- 13F period: 2026-06-30
- N-PORT fund positions: 27
- N-PORT value: $493.4M
- N-PORT report: 2026-05-31

## Top institutional holders (Form 13F)

_Showing 15 of 209 managers by value._

| Manager | Location | Value | Shares |
| --- | --- | --- | --- |
| FMR LLC | BOSTON, MA | $594.2M | 11,781,024 |
| BlackRock, Inc. | New York, NY | $278.5M | 5,521,221 |
| [RTW INVESTMENTS, LP](https://search.stillhousedata.com/firm/153232) | NEW YORK, NY | $210.4M | 4,171,996 |
| [Fairmount Funds Management LLC](https://search.stillhousedata.com/firm/284844) | WEST CONSHOHOCKEN, PA | $202.7M | 4,018,101 |
| [PERCEPTIVE ADVISORS LLC](https://search.stillhousedata.com/firm/154703) | NEW YORK, NY | $190.8M | 3,783,225 |
| [VR Adviser, LLC](https://search.stillhousedata.com/firm/169288) | NEW YORK, NY | $185.9M | 3,685,448 |
| Driehaus Capital Management LLC | Chicago, IL | $140.8M | 2,790,785 |
| [VANGUARD GROUP INC](https://search.stillhousedata.com/firm/105958) | Valley Forge, PA | $132.2M | 4,035,074 |
| STATE STREET CORP | BOSTON, MA | $131.5M | 2,607,031 |
| [Paradigm Biocapital Advisors LP](https://search.stillhousedata.com/firm/312544) | NEW YORK, NY | $98.7M | 1,957,266 |
| [COMMODORE CAPITAL LP](https://search.stillhousedata.com/firm/304370) | NEW YORK, NY | $96.5M | 1,912,380 |
| TCG Crossover Management, LLC | PALO ALTO, CA | $95.9M | 1,900,582 |
| TANG CAPITAL MANAGEMENT LLC | SAN DIEGO, CA | $95.4M | 1,892,200 |
| WELLINGTON MANAGEMENT GROUP LLP | BOSTON, MA | $92.0M | 1,824,811 |
| Capital International Investors | Los Angeles, CA | $88.1M | 1,746,129 |

## Top fund holders (N-PORT)

_Showing 15 of 27 fund positions by value._

| Fund | Registrant | Value | % of fund |
| --- | --- | --- | --- |
| [Fidelity Growth Company Fund](https://search.stillhousedata.com/fund/S000007119) | Fidelity Mt. Vernon Street Trust | $189.4M | 19.17% |
| [SMALLCAP World Fund Inc](https://search.stillhousedata.com/fund/S000009599) | SMALLCAP World Fund Inc | $121.7M | 15.02% |
| [T. Rowe Price Health Sciences Fund, Inc.](https://search.stillhousedata.com/fund/S000002088) | T. ROWE PRICE HEALTH SCIENCES FUND, INC. | $43.1M | 39.55% |
| [VANGUARD EXTENDED MARKET INDEX FUND](https://search.stillhousedata.com/fund/S000002841) | VANGUARD INDEX FUNDS | $38.4M | 4.71% |
| [Fidelity Advisor Health Care Fund](https://search.stillhousedata.com/fund/S000005329) | Fidelity Advisor Series VII | $30.5M | 105.73% |
| [VANGUARD RUSSELL 2000 INDEX FUND](https://search.stillhousedata.com/fund/S000030003) | VANGUARD SCOTTSDALE FUNDS | $28.2M | 16.08% |
| [Emerald Growth Fund](https://search.stillhousedata.com/fund/S000036390) | FINANCIAL INVESTORS TRUST | $11.4M | 81.20% |
| [Master Small Cap Index Series](https://search.stillhousedata.com/fund/S000002716) | Quantitative Master Series LLC | $5.7M | 11.86% |
| [PGIM Jennison Health Sciences Fund](https://search.stillhousedata.com/fund/S000004380) | Prudential Sector Funds, Inc. | $4.7M | 33.91% |
| [U.S. MICRO CAP PORTFOLIO](https://search.stillhousedata.com/fund/S000000948) | DFA INVESTMENT DIMENSIONS GROUP INC | $3.4M | 4.60% |
| [VANGUARD U.S. MOMENTUM FACTOR ETF](https://search.stillhousedata.com/fund/S000061302) | VANGUARD WELLINGTON FUND | $2.9M | 15.88% |
| [T. Rowe Price Health Sciences Portfolio](https://search.stillhousedata.com/fund/S000002083) | T. ROWE PRICE EQUITY SERIES, INC. | $2.7M | 40.15% |
| [VANGUARD BALANCED INDEX FUND](https://search.stillhousedata.com/fund/S000002560) | VANGUARD VALLEY FORGE FUNDS | $2.0M | 0.34% |
| [Fidelity Nasdaq Composite Index ETF](https://search.stillhousedata.com/fund/S000006011) | Fidelity Commonwealth Trust | $1.8M | 1.67% |
| [HARTFORD SMALL COMPANY HLS FUND](https://search.stillhousedata.com/fund/S000003220) | HARTFORD SERIES FUND INC | $1.8M | 44.99% |

## More

- [This page as markdown (for LLM agents)](https://search.stillhousedata.com/security/00773J202.md)
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Source: public SEC filing data via Adviser Search (https://search.stillhousedata.com).
Agents: this data is also queryable via MCP tools and read-only SQL — see https://search.stillhousedata.com/llms.txt.