# IONIS PHARMACEUTICALS INC COM

IONIS PHARMACEUTICALS INC COM is a security (CUSIP 462222100) tracked across SEC portfolio filings. 522 institutional managers reported $12.4B on Form 13F as of 2026-06-30; 63 registered fund positions totaling $3.1B via N-PORT as of 2026-05-31.

## Summary

- Issuer: IONIS PHARMACEUTICALS INC
- Class: COM
- CUSIP: 462222100
- Asset category: EC
- 13F holders: 522
- 13F value: $12.4B
- 13F period: 2026-06-30
- N-PORT fund positions: 63
- N-PORT value: $3.1B
- N-PORT report: 2026-05-31

## Top institutional holders (Form 13F)

_Showing 15 of 522 managers by value._

| Manager | Location | Value | Shares |
| --- | --- | --- | --- |
| FMR LLC | BOSTON, MA | $1.8B | 24,556,637 |
| Capital World Investors | LOS ANGELES, CA | $1.6B | 21,186,369 |
| [VANGUARD GROUP INC](https://search.stillhousedata.com/firm/105958) | Valley Forge, PA | $1.3B | 16,440,459 |
| BlackRock, Inc. | New York, NY | $784.1M | 10,442,476 |
| WELLINGTON MANAGEMENT GROUP LLP | BOSTON, MA | $480.0M | 6,391,816 |
| [TWO SIGMA INVESTMENTS, LP](https://search.stillhousedata.com/firm/137137) | New York, NY | $439.8M | 5,857,629 |
| [GEODE CAPITAL MANAGEMENT, LLC](https://search.stillhousedata.com/firm/115504) | BOSTON, MA | $305.2M | 3,984,332 |
| STATE STREET CORP | BOSTON, MA | $300.0M | 3,995,564 |
| Royal Bank of Canada | TORONTO, A6 | $285.5M | 3,801,815 |
| JPMORGAN CHASE & CO | NEW YORK, NY | $171.4M | 2,363,567 |
| [Tweedy, Browne Co LLC](https://search.stillhousedata.com/firm/6857) | Stamford, CT | $170.9M | 2,275,625 |
| [Artisan Partners Limited Partnership](https://search.stillhousedata.com/firm/150114) | Milwaukee, WI | $154.6M | 2,058,308 |
| [BAKER BROS. ADVISORS LP](https://search.stillhousedata.com/firm/158149) | NEW YORK, NY | $153.8M | 2,047,727 |
| DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C) | New York, NY | $148.7M | 1,979,669 |
| Deep Track Capital, LP | GREENWICH, CT | $146.4M | 1,950,000 |

## Top fund holders (N-PORT)

_Showing 15 of 63 fund positions by value._

| Fund | Registrant | Value | % of fund |
| --- | --- | --- | --- |
| [Fidelity Growth Company Fund](https://search.stillhousedata.com/fund/S000007119) | Fidelity Mt. Vernon Street Trust | $648.1M | 65.61% |
| [Growth Fund of America](https://search.stillhousedata.com/fund/S000009228) | Growth Fund of America | $586.7M | 16.25% |
| [New Economy Fund](https://search.stillhousedata.com/fund/S000009598) | New Economy Fund | $372.5M | 72.18% |
| [SMALLCAP World Fund Inc](https://search.stillhousedata.com/fund/S000009599) | SMALLCAP World Fund Inc | $334.8M | 41.31% |
| [VANGUARD HEALTH CARE FUND](https://search.stillhousedata.com/fund/S000002922) | VANGUARD SPECIALIZED FUNDS | $284.3M | 77.13% |
| [T. Rowe Price Mid-Cap Growth Fund, Inc.](https://search.stillhousedata.com/fund/S000002102) | T. ROWE PRICE MID-CAP GROWTH FUND, INC. | $207.3M | 92.02% |
| [VANGUARD EXTENDED MARKET INDEX FUND](https://search.stillhousedata.com/fund/S000002841) | VANGUARD INDEX FUNDS | $135.8M | 16.66% |
| [VANGUARD EXPLORER FUND](https://search.stillhousedata.com/fund/S000002578) | VANGUARD EXPLORER FUND | $89.4M | 41.07% |
| [Capital Group Growth ETF](https://search.stillhousedata.com/fund/S000074246) | Capital Group Growth ETF | $88.0M | 36.12% |
| [Select Fund](https://search.stillhousedata.com/fund/S000006194) | American Century Mutual Funds, Inc. | $71.9M | 112.49% |
| [T. Rowe Price Health Sciences Fund, Inc.](https://search.stillhousedata.com/fund/S000002088) | T. ROWE PRICE HEALTH SCIENCES FUND, INC. | $66.3M | 60.85% |
| [T. Rowe Price New Horizons Fund, Inc.](https://search.stillhousedata.com/fund/S000002106) | T. ROWE PRICE NEW HORIZONS FUND, INC. | $43.4M | 34.00% |
| [VANGUARD STRATEGIC EQUITY FUND](https://search.stillhousedata.com/fund/S000002593) | VANGUARD HORIZON FUNDS | $28.5M | 28.15% |
| [T. Rowe Price Diversified Mid-Cap Growth Fund, Inc.](https://search.stillhousedata.com/fund/S000002073) | T. ROWE PRICE DIVERSIFIED MID-CAP GROWTH FUND, INC. | $16.6M | 39.05% |
| [MFS New Discovery Value Fund](https://search.stillhousedata.com/fund/S000032712) | MFS SERIES TRUST XIII | $14.2M | 57.14% |

## More

- [This page as markdown (for LLM agents)](https://search.stillhousedata.com/security/462222100.md)
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Source: public SEC filing data via Adviser Search (https://search.stillhousedata.com).
Agents: this data is also queryable via MCP tools and read-only SQL — see https://search.stillhousedata.com/llms.txt.