# ORCHESTRA BIOMED HLDGS INC COM

ORCHESTRA BIOMED HLDGS INC COM is a security (CUSIP 68572M106) tracked across SEC portfolio filings. 76 institutional managers reported $96.1M on Form 13F as of 2026-06-30; 5 registered fund positions totaling $2.1M via N-PORT as of 2026-03-31.

## Summary

- Issuer: ORCHESTRA BIOMED HLDGS INC
- Class: COM
- CUSIP: 68572M106
- Asset category: EC
- 13F holders: 76
- 13F value: $96.1M
- 13F period: 2026-06-30
- N-PORT fund positions: 5
- N-PORT value: $2.1M
- N-PORT report: 2026-03-31

## Top institutional holders (Form 13F)

_Showing 15 of 76 managers by value._

| Manager | Location | Value | Shares |
| --- | --- | --- | --- |
| [RTW INVESTMENTS, LP](https://search.stillhousedata.com/firm/153232) | NEW YORK, NY | $35.3M | 8,306,063 |
| [PERCEPTIVE ADVISORS LLC](https://search.stillhousedata.com/firm/154703) | NEW YORK, NY | $21.4M | 5,037,906 |
| [VANGUARD GROUP INC](https://search.stillhousedata.com/firm/105958) | Valley Forge, PA | $6.7M | 1,604,556 |
| [Alyeska Investment Group, L.P.](https://search.stillhousedata.com/firm/155058) | CHICAGO, IL | $4.3M | 1,000,000 |
| [Propel Bio Management, LLC](https://search.stillhousedata.com/firm/322858) | LOS ANGELES, CA | $3.8M | 896,701 |
| MILLENNIUM MANAGEMENT LLC | NEW YORK, NY | $3.0M | 702,543 |
| BlackRock, Inc. | New York, NY | $2.7M | 635,714 |
| [GEODE CAPITAL MANAGEMENT, LLC](https://search.stillhousedata.com/firm/115504) | BOSTON, MA | $2.1M | 485,492 |
| [Affinity Asset Advisors, LLC](https://search.stillhousedata.com/firm/312788) | New York, NY | $1.7M | 402,550 |
| [CHARLES SCHWAB INVESTMENT MANAGEMENT INC](https://search.stillhousedata.com/firm/106753) | SAN FRANCISCO, CA | $1.1M | 265,499 |
| Knott David M Jr | Syosset, NY | $1.1M | 253,651 |
| [Simplify Asset Management Inc.](https://search.stillhousedata.com/firm/309535) | Las Vegas, NV | $947K | 219,387 |
| [MARSHALL WACE, LLP](https://search.stillhousedata.com/firm/160885) | LONDON, X0 | $801K | 188,484 |
| [683 Capital Management, LLC](https://search.stillhousedata.com/firm/156181) | NEW YORK, NY | $786K | 185,000 |
| STATE STREET CORP | BOSTON, MA | $720K | 169,410 |

## Top fund holders (N-PORT)

| Fund | Registrant | Value | % of fund |
| --- | --- | --- | --- |
| [VANGUARD EXTENDED MARKET INDEX FUND](https://search.stillhousedata.com/fund/S000002841) | VANGUARD INDEX FUNDS | $1.8M | 0.22% |
| [VANGUARD BALANCED INDEX FUND](https://search.stillhousedata.com/fund/S000002560) | VANGUARD VALLEY FORGE FUNDS | $147K | 0.02% |
| BlackRock Health Sciences Trust | BlackRock Health Sciences Trust | $75K | 1.41% |
| [VANGUARD INSTITUTIONAL TOTAL STOCK MARKET INDEX FUND](https://search.stillhousedata.com/fund/S000002855) | VANGUARD INSTITUTIONAL INDEX FUNDS | $64K | 0.02% |
| [Blackstone Alternative Multi-Strategy Fund](https://search.stillhousedata.com/fund/S000045538) | Blackstone Alternative Investment Funds | $264 | 0.00% |

## More

- [This page as markdown (for LLM agents)](https://search.stillhousedata.com/security/68572M106.md)
- [Search all SEC filings, advisers and people on Adviser Search](https://search.stillhousedata.com/)

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Source: public SEC filing data via Adviser Search (https://search.stillhousedata.com).
Agents: this data is also queryable via MCP tools and read-only SQL — see https://search.stillhousedata.com/llms.txt.