# PRELUDE THERAPEUTICS INC COM

PRELUDE THERAPEUTICS INC COM is a security (CUSIP 74065P101) tracked across SEC portfolio filings. 63 institutional managers reported $103.7M on Form 13F as of 2026-06-30; 6 registered fund positions totaling $1.1M via N-PORT as of 2026-05-29.

## Summary

- Issuer: PRELUDE THERAPEUTICS INC
- Class: COM
- CUSIP: 74065P101
- Asset category: EC
- 13F holders: 63
- 13F value: $103.7M
- 13F period: 2026-06-30
- N-PORT fund positions: 6
- N-PORT value: $1.1M
- N-PORT report: 2026-05-29

## Top institutional holders (Form 13F)

_Showing 15 of 63 managers by value._

| Manager | Location | Value | Shares |
| --- | --- | --- | --- |
| [ORBIMED ADVISORS LLC](https://search.stillhousedata.com/firm/118608) | New York, NY | $37.3M | 10,909,256 |
| [BAKER BROS. ADVISORS LP](https://search.stillhousedata.com/firm/158149) | NEW YORK, NY | $34.6M | 10,123,824 |
| [Kynam Capital Management, LP](https://search.stillhousedata.com/firm/314368) | PRINCETON, NJ | $5.4M | 1,592,551 |
| [VANGUARD GROUP INC](https://search.stillhousedata.com/firm/105958) | Valley Forge, PA | $4.1M | 1,413,986 |
| [EcoR1 Capital, LLC](https://search.stillhousedata.com/firm/167121) | San Francisco, CA | $3.2M | 947,049 |
| [TWO SIGMA INVESTMENTS, LP](https://search.stillhousedata.com/firm/137137) | New York, NY | $3.2M | 923,626 |
| [SPHERA FUNDS MANAGEMENT LTD.](https://search.stillhousedata.com/firm/312614) | TEL AVIV, L3 | $1.9M | 558,339 |
| MILLENNIUM MANAGEMENT LLC | NEW YORK, NY | $1.3M | 382,737 |
| [MARSHALL WACE, LLP](https://search.stillhousedata.com/firm/160885) | LONDON, X0 | $1.2M | 358,906 |
| MORGAN STANLEY | NEW YORK, NY | $1.1M | 322,161 |
| BlackRock, Inc. | New York, NY | $1.1M | 321,886 |
| [GEODE CAPITAL MANAGEMENT, LLC](https://search.stillhousedata.com/firm/115504) | BOSTON, MA | $1.0M | 302,458 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | BALA CYNWYD, PA | $988K | 267,788 |
| [RENAISSANCE TECHNOLOGIES LLC](https://search.stillhousedata.com/firm/106661) | NEW YORK, NY | $941K | 275,200 |
| GOLDMAN SACHS GROUP INC | NEW YORK, NY | $809K | 236,469 |

## Top fund holders (N-PORT)

| Fund | Registrant | Value | % of fund |
| --- | --- | --- | --- |
| [VANGUARD EXTENDED MARKET INDEX FUND](https://search.stillhousedata.com/fund/S000002841) | VANGUARD INDEX FUNDS | $900K | 0.11% |
| [VANGUARD INSTITUTIONAL TOTAL STOCK MARKET INDEX FUND](https://search.stillhousedata.com/fund/S000002855) | VANGUARD INSTITUTIONAL INDEX FUNDS | $63K | 0.02% |
| [U.S. MICRO CAP PORTFOLIO](https://search.stillhousedata.com/fund/S000000948) | DFA INVESTMENT DIMENSIONS GROUP INC | $45K | 0.06% |
| [VANGUARD BALANCED INDEX FUND](https://search.stillhousedata.com/fund/S000002560) | VANGUARD VALLEY FORGE FUNDS | $44K | 0.01% |
| [Blackstone Alternative Multi-Strategy Fund](https://search.stillhousedata.com/fund/S000045538) | Blackstone Alternative Investment Funds | $20K | 0.06% |
| Guggenheim Active Allocation Fund | Guggenheim Active Allocation Fund | $251 | 0.00% |

## More

- [This page as markdown (for LLM agents)](https://search.stillhousedata.com/security/74065P101.md)
- [Search all SEC filings, advisers and people on Adviser Search](https://search.stillhousedata.com/)

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Source: public SEC filing data via Adviser Search (https://search.stillhousedata.com).
Agents: this data is also queryable via MCP tools and read-only SQL — see https://search.stillhousedata.com/llms.txt.