# SEPTERNA INC COMMON STOCK

SEPTERNA INC COMMON STOCK is a security (CUSIP 81734D104) tracked across SEC portfolio filings. 126 institutional managers reported $1.1B on Form 13F as of 2026-06-30; 11 registered fund positions totaling $13.7M via N-PORT as of 2026-05-31.

## Summary

- Issuer: SEPTERNA INC
- Class: COMMON STOCK
- CUSIP: 81734D104
- Asset category: EC
- 13F holders: 126
- 13F value: $1.1B
- 13F period: 2026-06-30
- N-PORT fund positions: 11
- N-PORT value: $13.7M
- N-PORT report: 2026-05-31

## Top institutional holders (Form 13F)

_Showing 15 of 126 managers by value._

| Manager | Location | Value | Shares |
| --- | --- | --- | --- |
| RA CAPITAL MANAGEMENT, L.P. | Boston, MA | $168.1M | 6,995,858 |
| TRV GP V, LLC | Boston, MA | $149.4M | 6,215,591 |
| Driehaus Capital Management LLC | Chicago, IL | $105.6M | 4,395,572 |
| TRV GP VI, LLC | Boston, MA | $101.2M | 4,211,659 |
| [Samsara BioCapital, LLC](https://search.stillhousedata.com/firm/288114) | Palo Alto, CA | $75.7M | 3,149,128 |
| GOLDMAN SACHS GROUP INC | NEW YORK, NY | $69.8M | 2,906,427 |
| BlackRock, Inc. | New York, NY | $64.7M | 1,932,088 |
| Siren, L.L.C. | New York, NY | $48.1M | 2,000,000 |
| [VANGUARD GROUP INC](https://search.stillhousedata.com/firm/105958) | Valley Forge, PA | $42.0M | 1,508,195 |
| BVF INC/IL | San Francisco, CA | $32.5M | 1,353,249 |
| [Avoro Capital Advisors LLC](https://search.stillhousedata.com/firm/154091) | New York, NY | $32.1M | 1,337,500 |
| [ADAR1 Capital Management, LLC](https://search.stillhousedata.com/firm/299694) | AUSTIN, TX | $26.2M | 1,089,818 |
| [PRIMECAP MANAGEMENT CO/CA/](https://search.stillhousedata.com/firm/105516) | PASADENA, CA | $25.2M | 1,048,834 |
| STATE STREET CORP | BOSTON, MA | $21.9M | 652,630 |
| JANUS HENDERSON GROUP PLC | LONDON, X0 | $21.3M | 890,754 |

## Top fund holders (N-PORT)

| Fund | Registrant | Value | % of fund |
| --- | --- | --- | --- |
| [VANGUARD EXTENDED MARKET INDEX FUND](https://search.stillhousedata.com/fund/S000002841) | VANGUARD INDEX FUNDS | $6.2M | 0.76% |
| [VANGUARD RUSSELL 2000 INDEX FUND](https://search.stillhousedata.com/fund/S000030003) | VANGUARD SCOTTSDALE FUNDS | $3.3M | 1.89% |
| [VANGUARD U.S. MOMENTUM FACTOR ETF](https://search.stillhousedata.com/fund/S000061302) | VANGUARD WELLINGTON FUND | $1.5M | 8.03% |
| [Master Small Cap Index Series](https://search.stillhousedata.com/fund/S000002716) | Quantitative Master Series LLC | $873K | 1.81% |
| [Fidelity Nasdaq Composite Index ETF](https://search.stillhousedata.com/fund/S000006011) | Fidelity Commonwealth Trust | $524K | 0.48% |
| [VANGUARD BALANCED INDEX FUND](https://search.stillhousedata.com/fund/S000002560) | VANGUARD VALLEY FORGE FUNDS | $382K | 0.06% |
| [VANGUARD INSTITUTIONAL TOTAL STOCK MARKET INDEX FUND](https://search.stillhousedata.com/fund/S000002855) | VANGUARD INSTITUTIONAL INDEX FUNDS | $365K | 0.12% |
| [Russell Investments U.S. Small Cap Equity ETF](https://search.stillhousedata.com/fund/S000089990) | Russell Investments Exchange Traded Funds | $184K | 37.29% |
| [U.S. MICRO CAP PORTFOLIO](https://search.stillhousedata.com/fund/S000000948) | DFA INVESTMENT DIMENSIONS GROUP INC | $175K | 0.23% |
| [DWS Small Cap Index VIP](https://search.stillhousedata.com/fund/S000006223) | DEUTSCHE DWS INVESTMENTS VIT FUNDS | $72K | 1.71% |
| [Federated Hermes Global Allocation Fund](https://search.stillhousedata.com/fund/S000009117) | Federated Hermes Global Allocation Fund | $68K | 2.32% |

## More

- [This page as markdown (for LLM agents)](https://search.stillhousedata.com/security/81734D104.md)
- [Search all SEC filings, advisers and people on Adviser Search](https://search.stillhousedata.com/)

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Source: public SEC filing data via Adviser Search (https://search.stillhousedata.com).
Agents: this data is also queryable via MCP tools and read-only SQL — see https://search.stillhousedata.com/llms.txt.