UPSTREAM BIO INC COM

UPSTREAM BIO INC COM is a security (CUSIP 91678A107) tracked across SEC portfolio filings. 135 institutional managers reported $434.1M on Form 13F as of 2026-06-30; 17 registered fund positions totaling $12.0M via N-PORT as of 2026-05-31.

Summary

Top institutional holders (Form 13F)

Showing 15 of 135 managers by value.

ManagerLocationValueShares
FMR LLCBOSTON, MA$72.9M8,101,563
VANGUARD GROUP INCValley Forge, PA$64.8M2,388,439
ORBIMED ADVISORS LLCNew York, NY$51.2M5,693,589
BlackRock, Inc.New York, NY$30.3M3,370,689
Decheng Capital LLCMENLO PARK, CA$24.5M2,724,868
ENAVATE SCIENCES GP, LLCNew York, NY$22.1M2,459,703
FEDERATED HERMES, INC.Pittsburgh, PA$8.8M979,758
GEODE CAPITAL MANAGEMENT, LLCBOSTON, MA$8.6M950,617
MILLENNIUM MANAGEMENT LLCNEW YORK, NY$8.4M937,323
Bain Capital Life Sciences Investors, LLCBoston, MA$7.8M867,211
Woodline Partners LPSan Francisco, CA$7.5M831,481
D. E. Shaw & Co., Inc.New York, NY$7.4M820,480
Parkman Healthcare Partners LLCSTAMFORD, CT$7.1M786,783
Samsara BioCapital, LLCPalo Alto, CA$6.6M736,047
STATE STREET CORPBOSTON, MA$6.3M705,350

Top fund holders (N-PORT)

Showing 15 of 17 fund positions by value.

FundRegistrantValue% of fund
Fidelity Advisor Health Care FundFidelity Advisor Series VII$3.7M12.72%
VANGUARD EXTENDED MARKET INDEX FUNDVANGUARD INDEX FUNDS$3.5M0.42%
VANGUARD RUSSELL 2000 INDEX FUNDVANGUARD SCOTTSDALE FUNDS$1.4M0.80%
VANGUARD MARKET NEUTRAL FUNDVANGUARD MONTGOMERY FUNDS$1.1M25.01%
BlackRock Health Sciences Term TrustBlackRock Health Sciences Term Trust$509K5.03%
Master Small Cap Index SeriesQuantitative Master Series LLC$495K1.03%
BlackRock Health Sciences TrustBlackRock Health Sciences Trust$270K5.08%
U.S. MICRO CAP PORTFOLIODFA INVESTMENT DIMENSIONS GROUP INC$258K0.34%
VANGUARD BALANCED INDEX FUNDVANGUARD VALLEY FORGE FUNDS$238K0.04%
VANGUARD GROWTH AND INCOME FUNDVANGUARD QUANTITATIVE FUNDS$236K0.14%
Fidelity Disruptive Medicine ETFFidelity Covington Trust$208K50.80%
VANGUARD INSTITUTIONAL TOTAL STOCK MARKET INDEX FUNDVANGUARD INSTITUTIONAL INDEX FUNDS$184K0.06%
DWS Small Cap Index VIPDEUTSCHE DWS INVESTMENTS VIT FUNDS$42K1.01%
Gabelli Healthcare & WellnessRx TrustGabelli Healthcare & WellnessRx Trust$7K0.49%
TIAA Separate Account VA-1 - Stock Index AccountTIAA Separate Account VA-1$5K0.04%

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