SPYRE THERAPEUTICS INC COM NEW is a security (CUSIP 00773J202) tracked across SEC portfolio filings. 209 institutional managers reported $4.2B on Form 13F as of 2026-06-30; 27 registered fund positions totaling $493.4M via N-PORT as of 2026-05-31.
Showing 15 of 209 managers by value.
| Manager | Location | Value | Shares |
|---|---|---|---|
| FMR LLC | BOSTON, MA | $594.2M | 11,781,024 |
| BlackRock, Inc. | New York, NY | $278.5M | 5,521,221 |
| RTW INVESTMENTS, LP | NEW YORK, NY | $210.4M | 4,171,996 |
| Fairmount Funds Management LLC | WEST CONSHOHOCKEN, PA | $202.7M | 4,018,101 |
| PERCEPTIVE ADVISORS LLC | NEW YORK, NY | $190.8M | 3,783,225 |
| VR Adviser, LLC | NEW YORK, NY | $185.9M | 3,685,448 |
| Driehaus Capital Management LLC | Chicago, IL | $140.8M | 2,790,785 |
| VANGUARD GROUP INC | Valley Forge, PA | $132.2M | 4,035,074 |
| STATE STREET CORP | BOSTON, MA | $131.5M | 2,607,031 |
| Paradigm Biocapital Advisors LP | NEW YORK, NY | $98.7M | 1,957,266 |
| COMMODORE CAPITAL LP | NEW YORK, NY | $96.5M | 1,912,380 |
| TCG Crossover Management, LLC | PALO ALTO, CA | $95.9M | 1,900,582 |
| TANG CAPITAL MANAGEMENT LLC | SAN DIEGO, CA | $95.4M | 1,892,200 |
| WELLINGTON MANAGEMENT GROUP LLP | BOSTON, MA | $92.0M | 1,824,811 |
| Capital International Investors | Los Angeles, CA | $88.1M | 1,746,129 |
Showing 15 of 27 fund positions by value.
| Fund | Registrant | Value | % of fund |
|---|---|---|---|
| Fidelity Growth Company Fund | Fidelity Mt. Vernon Street Trust | $189.4M | 19.17% |
| SMALLCAP World Fund Inc | SMALLCAP World Fund Inc | $121.7M | 15.02% |
| T. Rowe Price Health Sciences Fund, Inc. | T. ROWE PRICE HEALTH SCIENCES FUND, INC. | $43.1M | 39.55% |
| VANGUARD EXTENDED MARKET INDEX FUND | VANGUARD INDEX FUNDS | $38.4M | 4.71% |
| Fidelity Advisor Health Care Fund | Fidelity Advisor Series VII | $30.5M | 105.73% |
| VANGUARD RUSSELL 2000 INDEX FUND | VANGUARD SCOTTSDALE FUNDS | $28.2M | 16.08% |
| Emerald Growth Fund | FINANCIAL INVESTORS TRUST | $11.4M | 81.20% |
| Master Small Cap Index Series | Quantitative Master Series LLC | $5.7M | 11.86% |
| PGIM Jennison Health Sciences Fund | Prudential Sector Funds, Inc. | $4.7M | 33.91% |
| U.S. MICRO CAP PORTFOLIO | DFA INVESTMENT DIMENSIONS GROUP INC | $3.4M | 4.60% |
| VANGUARD U.S. MOMENTUM FACTOR ETF | VANGUARD WELLINGTON FUND | $2.9M | 15.88% |
| T. Rowe Price Health Sciences Portfolio | T. ROWE PRICE EQUITY SERIES, INC. | $2.7M | 40.15% |
| VANGUARD BALANCED INDEX FUND | VANGUARD VALLEY FORGE FUNDS | $2.0M | 0.34% |
| Fidelity Nasdaq Composite Index ETF | Fidelity Commonwealth Trust | $1.8M | 1.67% |
| HARTFORD SMALL COMPANY HLS FUND | HARTFORD SERIES FUND INC | $1.8M | 44.99% |